REACH Priority Statements

National Cancer Institute (NCI)

The purpose of the Research in Emerging Areas Critical to Human Health (REACH) LRP is to recruit and retain highly qualified health professionals with doctoral-level degree(s) into research careers:

(1) where there are major gaps in biomedical and biobehavioral research; and/or
(2) to expand research in emerging areas critical to human health.

For the purposes of the REACH (L70) LRP, NCI will accept applications for funding consideration only that pursue research in cancer epidemiology, prevention, and/or cancer control and population sciences.

NCI will not accept translational cancer research applications submitted to the REACH LRP (L70) if they do not fit the research areas outlined above.

Dr. Mark Damico
240-276-5630
[email protected]

National Eye Institute (NEI)

The proposals dealing with innovative research to understand the eye and visual system, prevent and treat vision diseases, and expand opportunities for people who are visually impaired or require vision rehabilitation. The applications dealing with health disparities, data science, regenerative medicine, artificial intelligence (AI), machine learning, and bioinformatics related to visual disorders and vision science are also encouraged under LRP initiative.

National Heart Lung and Blood Institute (NHLBI)

The NHLBI will support the REACH LRP for clinician scientists proposing research on any topic of strategic importance to NHLBI across its portfolio of heart, lung, blood, and sleep diseases and disorders. The research can span any stage along the research spectrum from basic science to late-stage translation and implementation science. Applications that qualify under other existing LRP programs supported by NHLBI are not responsive to this program.

Candidates must hold a degree including, but not limited to M.D., Pharm. D., Psy.D., D.O., D.D.S., D.M.D., D.P.M., D.C., N.D., O.D., D.V.M., or equivalent doctoral-level degree from an accredited institution. Individuals with a Ph.D. or other equivalent doctoral degree in clinical disciplines such as clinical psychology, nursing, clinical genetics, speech-language pathology, audiology or rehabilitation are also eligible. Individuals holding a Ph.D. in a non-clinical discipline but who are certified to perform clinical duties should contact NHLBI to determine eligibility.

Dr. Shilpy Dixit
[email protected]

National Human Genome Research Institute (NHGRI)

NHGRI will support genetic counselors at the master’s and doctoral levels who are involved in genomics research offering their intellectual expertise either as part of a team or as an independent researcher. The research focus must be toward advancing the science of genomic medicine and the incorporation of genomics in improving the effectiveness of health care. NHGRI is strongly committed to supporting genomics research that addresses health disparities.

National Institute on Aging (NIA)

NIA will accept applications for the REACH LRP with aging-focused research projects on artificial intelligence, machine learning, robotics, management strategies for multiple chronic conditions, deprescribing, approaches to tele/virtual functional assessment, resilience, and geroscience-related interventions in older adults and aging populations.

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NIAAA supports research on alcohol use in several scientific areas including epidemiology and prevention, basic and clinical studies to identify mechanisms of organ and tissue damage and effects on brain systems and behavior, as well as research on behavioral and pharmacological approaches to treating alcohol-related problems and promoting recovery from alcohol use disorder. For the LRP-REACH program, NIAAA is particularly interested in investigators with basic science projects in the areas of metabolism and physiological and pathological health effects or neuroscience and behavior. Studies investigating biological mechanisms on the molecular, cellular and organ level are encouraged. Preclinical studies for the development of medications will also be considered.

NIAAA will also support projects using computational and data science approaches in alcohol research, including developing new software applications or algorithms for analysis and integration of NIAAA and public data sets. Projects with computational or systems biology models of alcohol exposure on molecular, cellular, organ, network and organism models from initial alcohol exposure and extending through alcohol use disorder, treatment and recovery will be considered appropriate.

Dr. Elizabeth Powell
301-443-0786
[email protected]

National Institute of Allergy and Infectious Diseases (NIAID)

The mission of the National Institute of Allergy and Infectious Diseases (NIAID) is to conduct and support basic and applied research to better understand, treat, and ultimately prevent infectious, immunologic, and allergic diseases. In addition, NIAID has a unique mandate which requires the Institute to respond to emerging public health threats. The NIAID will consider applications for the REACH LRP in the next fiscal year that fall within the Institute’s mission areas and do not meet the eligibility criteria for the Clinical, Pediatric, or Health Disparities subcategories as defined by the NIH LRP.

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

NIAMS will accept applications from all applicants in:

• Basic research in the etiology of acute and chronic pain in musculoskeletal and autoimmune and skin disorders,
• Dissemination and Implementation research, and
• Data Science research.

National Institute of Biomedical Imaging and Bioengineering (NIBIB)

For the REACH LRP, NIBIB will accept applications that propose research within NIBIB’s interests but do not meet the research eligibility requirements for Clinical, Pediatric or Health Disparities as defined by the Loan Repayment Program at www.lrp.nih.gov/apply. NIBIB’s interests include the development and integration of advanced bioengineering, sensing, imaging, and computational technologies for the improvement of human health and medical care. Applicants are strongly encouraged to contact the NIBIB LRP Liaison before they begin to prepare their application https://www.lrp.nih.gov/contact-engage.

Dr. Tina Gatlin
301-480-1608
[email protected]

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NICHD will consider funding applications for the REACH LRP that (1) do not meet the research project eligibility requirements for any of the other LRP programs supported by NICHD, (2) do meet all other LRP eligibility requirements, and (3) are submitted by applicants whose research efforts will pursue one or more Priority topics listed at the web pages for NICHD’s extramural branches or that of the National Center for Medical Rehabilitation Research and (4) cite the Priority topic(s) they will pursue and the URL of the NICHD web page on which those topics appear.

National Institute on Deafness and Other Communication Disorders (NIDCD)

Applicants are strongly encouraged to contact NIDCD before submitting an application and provide a 1-page statement addressing each REACH LRP objectives and NIDCD priorities listed below.

LRP-REACH Objective

• The objective of the LRP-REACH is to recruit and retain highly qualified health professionals into research careers to pursue major gaps in biomedical and biobehavioral research and/or expand research in emerging areas critical to human health.
• Emerging areas are considered new areas of biomedical and biobehavorial research that are ripe for targeted investments that can have a transformative relevance and impact for years to come.

NIDCD Priorities

• NIDCD's priorities include investigators conducting basic and clinical research in emerging NIDCD-relevant research priority scientific areas as described in the NIDCD Strategic Plan.

National institute of Dental and Craniofacial Research (NIDCR)

A high priority for the NIDCR is developing and sustaining a robust dentist-scientist research workforce. The dentist-scientist research workforce is vital for the expertise it brings to identifying important clinical questions that drive basic discoveries, enhancing diagnostic and therapeutic approaches, and improving dental, oral and craniofacial health.

The intent of the NIDCR REACH is to provide an opportunity for dentist-scientists, whose research is in areas outside of the NIH clinical, pediatric or health disparities LRP research programs. The REACH program will accept applications from dentist-scientists performing oral health research that align with the NIDCR Extramural Grant Programs and do not meet the eligibility criteria for the NIH Clinical, Clinical for Disadvantaged Backgrounds, Pediatric, or Health Disparities Loan Repayment Programs.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIDDK will accept applications for the REACH LRP that are within the mission of NIDDK but do not meet the research eligibility requirements for Clinical, Pediatric or Health Disparities as defined by the Loan Repayment Program at www.lrp.nih.gov/apply

National Institute on Drug Abuse (NIDA)

NIDA will be accepting LRP REACH applications for each of the following categories:

• Forensic Pathologists and Medical Examiners working in the field of drug overdose
• Addiction scientists working in drug development
• Data Scientists/Computational Neuroscientists focusing on addiction

For eligibility questions please visit lrp.nih.gov or contact NIDAs LRP office at [email protected].

National Institute of Environmental Health Sciences (NIEHS)

For the purposes of the REACH LRP, applications in the following emerging areas and/or sub-areas will be prioritized:

• Microbiome-relevant research that characterizes the interaction among host biological pathways, environmental exposures, and resident microbial communities
  • Development of strategies to determine causality between environmental exposures and changes in microbiome composition.
  • Development of microbial-based intervention approaches for toxicity or exposure-related health outcomes.
• Research that utilizes or promotes the utilization of exposomics in human health studies
  • Developing innovative tools and methodologies to improve exposure assessment or enable measurement of emerging environmental exposures.
  • Integrating multiscale exposure data with health data to gain holistic view of the relationship between exposure and disease.
  • Using a systems approach to study the exposure-response interface for better understanding of complex effects of the environment.
• Research that develops and/or applies advanced data science tools and methodologies to address environmental health research questions
  • Developing computational tools, software, and infrastructures to share, integrate, and analyze environmental health data.
  • Applying methods from data science fields, including Artificial Intelligence, Machine Learning, Statistical Modeling and Analysis, Graph Theory, and Semantic Engineering to solve environmental health problems.
  • Leading community-based development of data and metadata standards for environmental health, including standardized vocabularies and ontologies.
• Innovative research related to integrating large-scale genomics and environmental data in population studies to understand gene-environment interactions in complex disease.
• Innovative research related to use of new functional genomics tools and technologies to understand genetic susceptibility to environmental exposures.
• Innovative research related to the impacts of climate change on human health.
• Innovative research related to human health effects from ocean or freshwater (e.g., Great Lakes) environmental exposures.
• Novel research on the etiology of environmental health disparities (EHD) and/or translation of existing EHD research into evidence-based prevention and interventions to reduce health disparities and move toward environmental justice.
• Inventive research that examines the intersection of individual and structural-level social determinants of health and environmental exposures.

NIEHS makes its funding decisions based on scientific merit responsiveness to the Institute's priorities and availability of funds.

National Institute of Mental Health (NIMH)

The NIMH REACH LRP will only accept applications from investigators with clinically oriented degrees who are licensed to practice medicine and conduct basic research aligned with NIMH’s strategic plan.

Applications that qualify under other existing LRP programs supported by NIMH are not responsive to this program.

National Institute on Minority Health and Health Disparities (NIMHD)

For the Research in Emerging Areas Critical to Human Health (REACH) program, NIMHD supports applications in the following areas:

• Maternal morbidity
• Prevention of multiple chronic diseases
• Social epigenomics research
• Suicide
• Health effects and impact on health care systems/services of rapid environmental change
• Firearm related injuries and mortalities
• Sleep health disparities
• Data science in health disparities
• Health IT and management of chronic disease
• Multi-level, Multi-domain analysis
• Immigrant health

LCDR Michael Banyas, USPHS, M.P.A., M.A. (candidate)
240-619-9483 [email protected]

National Institute of Neurological Disorders and Stroke (NINDS)

NINDS encourages LRP applications from any individual who is conducting research within the NINDS mission that

1. Will fill an important gap in knowledge about the mechanisms or treatment of neurological disorders and diseases
2. Will fill an important gap in understanding basic biological processes that are critical to understanding how disease alters neurological function
3. Will expand research or open new avenues of investigation into neurological disorders and diseases.

General NINDS priorities and policies regarding the LRP can be found at https://www.ninds.nih.gov/Funding/Apply-Funding/Loan-Repayment-Programs.

National Institute of Nursing Research (NINR)

The mission of the National Institute of Nursing Research (NINR) is to lead nursing research to solve pressing health challenges and inform practice and policy– optimizing health and advancing health equity into the future. NINR will give priority to applicants from any discipline with a clear commitment to discovering solutions to health challenges through the lenses of health equity, social determinants of health, population and community health, prevention and health promotion, and systems and models of care.

National Library of Medicine (NLM)

NLM will accept applications for the REACH LRP that are Informatics/Data Science-focused research projects that do not meet the research eligibility requirements for Clinical, Pediatric or Health Disparities as defined by the LRP, and apply artificial intelligence, machine learning, or use of big data to a health-related domain.

John E. Fogarty International Center (FIC)

FIC promotes and supports scientific research and training internationally to broadly advance global health. FIC will support the REACH LRP for scientists proposing research in World Bank-classified low- and middle-income countries (LMICs) on any topic of strategic importance to FIC, at any stage along the research spectrum from basic science to late-stage translation and implementation science.

Apply to the NIH institute or center that most closely aligns with your area of research. FIC cannot be listed as the primary institution on applications but can be listed as a secondary institution. FIC is looking for applicants whose research is consistent with the mission of the Center. Candidates must hold a degree including, but not limited to Ph.D., M.D., Pharm. D., Psy.D., D.O., D.D.S., D.M.D., D.P.M., D.C., N.D., O.D., D.V.M., or equivalent doctoral-level degree from an accredited institution. Selection priority is given to current and former FIC trainees and grantees.

National Center for Advancing Translational Sciences (NCATS)

NCATS will support investigators at the master’s and doctoral levels with expertise in:

• Data science and health informatics to provide clinical decision support of health care providers
• Telehealth and mobile health research approaches to improve the health of under-served and under-represented populations.

National Center for Complementary and Integrative Health (NCCIH)

NCCIH accepts applications to the Clinical Research, Pediatric Research, Health Disparities Research, and REACH Loan Repayment Programs. NCCIH’s mission is to define, through rigorous scientific investigation, the usefulness and safety of complementary and integrative health interventions and their roles in improving health and health care. All applications must be aligned to NCCIH's mission research priorities and strategic plan. Specific for the REACH LRP, NCCIH’s specific interest include the following:

• Research to advance the understanding of biological mechanisms underlying clustered symptoms (e.g., co-occurring chronic pain, sleep difficulties, anxiety, and depression)
• Development of algorithms that predict intervention efficacy from baseline factors (e.g., better understanding of what works for whom and under what conditions)
• Dissemination and implementation science research for complementary and integrative health interventions with proven efficacy
• Development of novel tools, methodologies and technologies for the analysis of complex natural products chemical and/or biological data to rapidly identify active components of complex mixtures
• Exploring impact and/or contribution of microbial metabolism of orally consumed natural products (not amino acids or fiber) on observed biological activity; also exploring role of orally consumed phytochemicals (not amino acids or fiber) on function of gut microflora
• Inclusion of pharmacokinetic analysis for natural products including assessments of bioavailability and interaction with Phase I and Phase II metabolizing enzymes and transporters
• Early phase preclinical exploratory natural product discovery for pain as appropriate
• Developing and testing pilot reliable objective measures of pain outcomes generated by injuries to peripheral tissues such as muscles, fascia, connective tissues, joints, and others
• Developing and testing measures, outcomes and endpoints of pain in patients of sickle cell disease
• Developing and testing in vivo labeling technology of tissues or cells responsible for generating signals in response to different internal senses (e.g. mechanical force, temperature, osmolarity, oxygen levels)
• Developing and testing technology or methods quantifying biomechanical forces applied to internal tissues or cells
• Exploring the innovative mechanisms of action of sensory-based complementary and integrative approaches

Office of Research Infrastructure Programs (ORIP)

Apply to the NIH institute or center that most closely aligns with your area of research. ORIP cannot be listed as the primary institution but can be listed as a secondary institution on new applications.

For the REACH loan repayment program, ORIP supports applicants with the D.V.M./V.M.D. or equivalent degree that use animal models to pursue major gaps in biomedical and biobehavioral research and expand research in emerging areas critical to human health. Proposed research investigations must be applicable to the interests of two or more of the categorical NIH Institutes and Centers. In addition, projects that predominantly address the research interests of one NIH Institute or Center, but that are peripherally related to the research interests of other Institutes and Centers, will not be considered appropriate. An example of an inappropriate request is one exclusively involving an animal model of cancer or some other specific disease. Plans for translation of basic research to clinical use would be an essential component of REACH awards supported by ORIP.

Office of Research on Women's Health (ORWH)

ORWH focuses on advancing research that is relevant to the health of women and supporting women in biomedical careers. Applicants should ensure their proposed work intersects with the goals, objectives, and guiding principles of the trans-NIH Strategic Plan for Women’s Health Research. ORWH does not award grants but co-funds applications and research projects that have received an award from one of the participating NIH Institutes and Centers listed in the announcement. Visit the ORWH website or contact the appropriate ORWH staff to learn more.

For future communications, please reach out to Dr. Carolyn Bondar who will be the scientific program contact of ORWH to this working group.

Dr. Carolyn Bondar
[email protected]